Transcriptomics

Dataset Information

0

A MIR17HG-derived Long Noncoding RNA Provides an Essential Chromatin Scaffold for Protein Interaction and Myeloma Growth [array]


ABSTRACT: Long noncoding RNAs (lncRNA) can drive tumorigenesis and are susceptible to therapeutic intervention. Here, we used a large-scale CRISPR interference viability screen to interrogate cell growth dependency to lncRNA genes in multiple myeloma (MM), and identified a prominent role for the miR-17-92 cluster host gene (MIR17HG). We show that a MIR17HG-derived lncRNA, named lnc-17-92, is the main mediator of cell growth dependency acting in a microRNA- and DROSHA- independent manner. Lnc-17-92 provides a chromatin scaffold for the functional interaction between c-MYC and WDR82, thus promoting the expression of ACC1, the rate-limiting enzyme of de novo lipogenesis. Targeting MIR17HG pre-RNA with clinically applicable antisense molecules disrupts the transcriptional and functional activities of lnc-17-92, causing potent anti-tumor effects both in vitro and in vivo in three pre-clinical animal models, including a clinically relevant PDX-NSG mouse model. This study establishes a novel oncogenic function of MIR17HG and provides potent inhibitors for translation to clinical trials.

ORGANISM(S): Homo sapiens

PROVIDER: GSE208598 | GEO | 2025/07/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2025-07-01 | GSE208597 | GEO
2023-09-10 | GSE241826 | GEO
2021-09-09 | PXD018052 | Pride
2018-11-07 | PXD011577 | Pride
2025-05-24 | GSE268287 | GEO
2020-06-08 | GSE147851 | GEO
2019-11-10 | GSE123671 | GEO
2017-01-10 | GSE80493 | GEO
2017-01-10 | GSE80492 | GEO
2014-05-29 | GSE57507 | GEO