Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)
SUBMITTER: Maximilian Kauer
PROVIDER: GSE80493 | GEO | 2017-01-10
SECONDARY ACCESSION(S): PRJNA319049
REPOSITORIES: GEO
Action | DRS | |||
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GSE80493_RAW.tar | Raw | |||
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Schwentner Raphaela R Herrero-Martin David D Kauer Maximilian O MO Mutz Cornelia N CN Katschnig Anna M AM Sienski Grzegorz G Alonso Javier J Aryee Dave N T DN Kovar Heinrich H
Oncotarget 20170201 7
MicroRNAs serve to fine-tune gene expression and play an important regulatory role in tissue specific gene networks. The identification and validation of miRNA target genes in a tissue still poses a significant problem since the presence of a seed sequence in the 3'UTR of an mRNA and its expression modulation upon ectopic expression of the miRNA do not reliably predict regulation under physiological conditions. The chimeric oncoprotein EWS-FLI1 is the driving pathogenic force in Ewing sarcoma. M ...[more]