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Cancer-specific miRNAs Extracted from Tissue-exudative Ex-tracellular Vesicles in Ovarian Clear Cell Carcinoma

ABSTRACT: Ovarian clear cell carcinomas (OCCs) arise from endometriotic cysts that many women develop. Because the prognosis for OCC is poor, there is a need to identify biomarkers for early detection of OCC. Extracellular vesicles have attracted attention as biomarker carriers. This study aimed to identify cancer-specific miRNAs as novel OCC biomarkers using tissue-exudative extracellular vesicles (Te-EVs). Te-EVs were collected from patients with OCC on one side and a normal ovary on the other side. RNA sequencing was performed to identify cancerspecific miRNAs in Te-EVs. We identified tissue-specific miRNAs in the EVs secreted by OCC tissues. These EV miRNAs can be used as biomarkers for the early diagnosis and detection of OCC.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE214239 | GEO | 2022/10/01

REPOSITORIES: GEO

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