Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs

ABSTRACT: Most T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. There is evidence that CD27 engagement on conventional T lymphocytes favors the development of Th1 and cytotoxic responses in mice and humans, but the impact on the regulatory lineage is unknown. In this report, we examined the effect of constitutive CD27 engagement on both regulatory and conventional CD4+ T cells in vivo, in the absence of intentional antigenic stimulation. Our data show that both T cell subsets convert into type 1 effectors, characterized by cell activation, cytokine production, response to IFN-and CXCR3-dependent migration to inflammatory sites. Our data highlight the role of the transcription factor Eomes in this process. We conclude that CD27 may regulate the development of Th1 immunity in peripheral tissues as well as the subsequent switch of the effector response into long-term memory.

ORGANISM(S): Mus musculus

PROVIDER: GSE214395 | GEO | 2022/11/30

REPOSITORIES: GEO