Effect of obesity and dyslipidemia on DNA hydroxymethylation in human adipose-derived mesenchymal stem/stromal cells [Homo sapiens]

ABSTRACT: Mesenchymal stem/stromal cells (MSCs) were harvested from subcutaneous adipose tissue of patients with obesity or healthy controls and expanded for 3-4 passages, and 5hmC profiles were examined through hydroxymethylated DNA immunoprecipitation sequencing (hMeDIP-seq). We hypothesized that obesity and cardiovascular risk factors induce functionally-relevant, locus-specific changes in overall exonic coverage of 5hmC in human adipose-derived MSCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE216948 | GEO | 2023/05/03

REPOSITORIES: GEO