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Comparison by microarray analysis between control and Nutlin 3b treatment in human senescent cells

ABSTRACT: We found that an aberrant interaction between glycolytic PGAM1 and Chk1 kinase is augmented in senescent cells. Chemical abrogation of PGAM1-Chk1 binding by Nutlin 3b blocks its interaction, followed by elimination of senescent cells, senolysis. To examine the molecular mechanism of senolysis by inhibition of PGAM1-Chk1 binding, transcriptomic analysis was performed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE217601 | GEO | 2025/12/15

REPOSITORIES: GEO

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Comparison by microarray analysis between control and Nutlin 3b treatment in human senescent cells

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