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FAO-fueled OXPHOS and NRF2-mediated stress resilience in MICs drive lymph node metastasis

ABSTRACT: The lymph nodes (LN) are the most frequent metastatic sites of esophageal squamous cell carcinoma (ESCC), but the associated mechanisms are poorly understood. Tumor cells lodge and survive at the metastatic site during the early adaptation step, which is the bottleneck for successful metastasis. However, the phenotypic and molecular characteristics of tumor cells that contribute to this key process remain elusive. Here, we established a robust human xenograft spontaneous LN metastasis model to capture individual cancer cells and used single-cell RNA sequencing to profile transcriptomic changes in cancer cells during different steps of metastasis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE220108 | GEO | 2025/03/29

REPOSITORIES: GEO

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FAO-fueled OXPHOS and NRF2-mediated stress resilience in MICs drive lymph node metastasis

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Tumor metastasis to lymph node requires YAP-dependent metabolic adaptation

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Immune Landscape of Intrathoracic Lymph Nodes with Metastasis in Primary Lung Malignancy using EBUS-TBNA samples

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