Transcriptomics,Genomics

Dataset Information

63

Whole tissue mRNA expression from severely obese individuals: subcutaneous and visceral adipose tissues


ABSTRACT: Subcutaneous adipose tissue and visceral adipose tissue samples were obtained from severely obese individuals that underwent bariatric surgery. The goal of this study was to compare genome-wide gene expression levels in the two tissue types from healthy and unhealthy severely obese individuals. Whole-transcriptome subcutaneous adipose tissue gene expression levels were determined in 73 individuals with a BMI >35 kg/m2. Whole-transcriptome visceral adipose tissue gene expression levels were determined in 69 individuals with a BMI >35 kg/m2. Modules of co-expressed genes likely to be functionally related were identfied and correlated with BMI, plasma levels of glucose, insulin, HbA1c, triglycerides, non-esterified fatty acids, ALAT, ASAT, C-reactive protein, and LDL- and HDL cholesterol. Overall design: Gene expression data was determined for untreated whole subcutaneous adipose tissue (n=73) from unrelated Dutch severely obese individuals. Gene expression data was determined for untreated whole visceral adipose tissue (n=69) from unrelated Dutch severely obese individuals.

INSTRUMENT(S): Illumina HumanHT-12 V3.0 expression beadchip

SUBMITTER: Lude Franke  

PROVIDER: GSE22070 | GEO | 2010-06-03

SECONDARY ACCESSION(S): PRJNA128947

REPOSITORIES: GEO

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Publications

Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray study.

Wolfs Marcel G M MG   Rensen Sander S SS   Bruin-Van Dijk Elinda J EJ   Verdam Froukje J FJ   Greve Jan-Willem JW   Sanjabi Bahram B   Bruinenberg Marcel M   Wijmenga Cisca C   van Haeften Timon W TW   Buurman Wim A WA   Franke Lude L   Hofker Marten H MH  

BMC medical genomics 20100805


<h4>Background</h4>Excessive accumulation of body fat, in particular in the visceral fat depot, is a major risk factor to develop a variety of diseases such as type 2 diabetes. The mechanisms underlying the increased risk of obese individuals to develop co-morbid diseases are largely unclear.We aimed to identify genes expressed in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) that are related to blood parameters involved in obesity co-morbidity, such as plasma lipid and glu  ...[more]

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