Genomics

Dataset Information

53

Expression data from quadriceps muscle of WT and ERRgamma transgenic mice


ABSTRACT: We show that the orphan nuclear receptor ERRg is expressed at high levels in type I muscle and when transgenically expressed in anaerobic type II muscles (ERRGO mice) or cultured cells, powerfully regulates VEGF expression, angiogenesis and vascular supply in absence of exercise. ERRGO mice show increased expression of genes promoting fat metabolism, mitochondrial respiration and type I fiber specification. In parallel, the type II muscle in ERRGO mice display an activated angiogenic program marked by myofibrillar induction and secretion of pro-angiogenic factors, frank neo-vascularization and a 100% increase in running endurance. Surprisingly, the induction of VEGF and type I muscle properties by ERRg does not involve the transcriptional co-activator PGC1a. Instead, ERRg genetically activates the energy sensor AMPK which is typically inactive in absence of exercise. Therefore, ERRg and AMPK, known regulators of mitochondrial function and metabolism, together control a novel angiogenic pathway that anatomically synchronizes vascular arborization to oxidative metabolism revealing an exercise-independent mechanism for matching supply and demand. Keywords: ERRgamma overexpression compared to wild-type Overall design: Comparison of gene expression from quadriceps muscles isolated from wild type and alpha-skeletal actin-ERRgamma-transgenic mice.

INSTRUMENT(S): [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

ORGANISM(S): Mus musculus  

SUBMITTER: Ruth T Yu 

PROVIDER: GSE22086 | GEO | 2011-09-19

SECONDARY ACCESSION(S): PRJNA128935

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE22086_RAW.tar Raw
filelist.txt Txt
Items per page:
1 - 2 of 2

Similar Datasets

2011-09-18 | E-GEOD-22086 | ArrayExpress
2011-01-01 | S-EPMC3084588 | BioStudies
2020-01-01 | S-EPMC7406804 | BioStudies
2017-01-01 | S-EPMC5735290 | BioStudies
1000-01-01 | S-EPMC3986832 | BioStudies
2010-01-01 | S-EPMC3229281 | BioStudies
2019-01-01 | S-EPMC7439921 | BioStudies
1000-01-01 | S-EPMC2781986 | BioStudies
2019-06-03 | GSE93546 | GEO
1000-01-01 | S-EPMC2795492 | BioStudies