Ontology highlight
ABSTRACT:
INSTRUMENT(S): Agilent-016436 Human miRNA Microarray 1.0 G4472A (miRNA ID version)
ORGANISM(S): Homo Sapiens
SUBMITTER: Laura Bonifacio
PROVIDER: GSE22134 | GEO | 2010-06-05
SECONDARY ACCESSION(S): PRJNA127569
REPOSITORIES: GEO
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PloS one 20100901 9
Senescence is a highly regulated process that limits cellular replication by enforcing a G1 arrest in response to various stimuli. Replicative senescence occurs in response to telomeric DNA erosion, and telomerase expression can offset replicative senescence leading to immortalization of many human cells. Limited data exists regarding changes of microRNA (miRNA) expression during senescence in human cells and no reports correlate telomerase expression with regulation of senescence-related miRNAs ...[more]