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Scavenger receptor A ameliorates acetaminophen induced hepatic inflammation

ABSTRACT: Acetaminophen-induced liver injury (AILI) occurs frequently and can be life threatening. Although AILI is mainly caused by the direct drug cytotoxicity, increasing evidence suggests that the interplay between hepatocytes and immune cells can define this pathogenic process. To further understand the immunoregulatory role of SRA in AILI, we performed RNA-sequencing analysis using hepatic nonparenchymal cells (NPCs) derived from acetaminophen treated WT or SRA-/- mice to demonstrate hepatocyte-extrinsic mechanisms governed by the immune receptor SRA that maintains liver homeostasis upon drug insult.

ORGANISM(S): Mus musculus

PROVIDER: GSE221747 | GEO | 2023/12/23

REPOSITORIES: GEO

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