Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult – SWATH proteomics
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ABSTRACT: The well-known difference in sensitivity of mice and rats to acetaminophen (APAP) liver injury has been related to differences in the fraction that is bioactivated to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). Physiologically-based pharmacokinetic modelling was used to identify doses of APAP (300 and 1000 mg/kg in mice and rats, respectively) yielding similar hepatic burdens of NAPQI, to enable the comparison of temporal liver tissue responses under conditions of equivalent chemical insult.
INSTRUMENT(S): TripleTOF 6600
ORGANISM(S): Rattus Norvegicus (rat) Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: Giusy Russomanno
LAB HEAD: Ian Copple
PROVIDER: PXD034438 | Pride | 2023-08-31
REPOSITORIES: Pride
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