Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE223180 | GEO | 2023/05/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [triplicates]

Project description:To investigate the cooperative function of dermal fibroblast and mast cell in inducing mast cell tolerance to commensals We then performed gene expression profiling analysis using data obtained from RNA-seq of mast cells, and mast cells conditioned by dermal fibroblasts before and after treatments with commensal bacteria supernatants.

2023-05-02 | GSE223179 | GEO

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [LTA]

2023-05-02 | GSE223177 | GEO

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [single-cell RNA-seq]

Project description:To investigate the cooperative function of dermal fibroblast and mast cell in inducing mast cell tolerance to commensals We then performed gene expression profiling analysis using data obtained from SC RNA seq of mast cells, dermal fibroblast and and mast cells in co culture with dermal fibroblasts .

2023-05-02 | GSE223178 | GEO

Bacteria Induce Skin Regeneration via IL-1 Signaling

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-04-01 | GSE158895 | GEO

Correcting Direct Effects of Ethanol on Translation and Transcription Machinery Confers Ethanol Tolerance in Bacteria

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-06-18 | E-GEOD-56408 | biostudies-arrayexpress

Toxification of polycyclic aromatic hydrocarbons by commensal bacteria from human skin.

Project description: Not available

| S-EPMC5429354 | biostudies-literature

Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.

Project description: Not available

| S-EPMC6709532 | biostudies-literature

RNA-seq of Arabidopsis thaliana roots exposed to the MAMP flg22 in the presence of commensal bacteria

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-03-27 | GSE156426 | GEO

Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury.

Project description: Not available

| S-EPMC2880863 | biostudies-literature

Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice

Project description:Type I interferons (IFNs) exert a broad range of biological effects important in coordinating immune responses, which have classically been studied in the context of pathogen clearance. Yet, whether immunomodulatory bacteria operate through IFN pathways to support intestinal immune tolerance remains elusive. Here, we reveal that the commensal bacterium, Bacteroides fragilis, utilizes canonical antiviral pathways to modulate intestinal dendritic cells (DCs) and regulatory T cell (Treg) responses. Specifically, IFN signaling is required for commensal-induced tolerance, as IFNAR1-deficient DCs display blunted IL-10 and IL-27 production in response to B. fragilis. We further establish that IFN-driven IL-27 in DCs is critical in shaping the ensuing Foxp3+ Treg via IL27Ra signaling. Consistent with these findings, single cell RNA sequencing of gut Tregs demonstrated that colonization with B. fragilis promotes a distinct IFN gene signature in Foxp3+ Tregs during intestinal inflammation. Altogether, our findings demonstrate a critical role of commensal-mediated immune tolerance via tonic type I IFN signaling.

2023-12-05 | GSE248021 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data