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A biodegradable, flexible photonic patch for in vivo phototherapy

ABSTRACT: Therapeutic and diagnostic illumination on internal organs and tissues with high controllability and adaptability in terms of spectrum, area, depth, and intensity remains a major challenge. Here, we present a flexible, biodegradable photonic device iCarP featured with a micrometer scale air gap constructed between a refractive polyester patch and the embedded removable tapered optical fiber (TOF). ICarP combines the advantages of light diffraction by TOF, dual refractions on TOF/air and air/patch interfaces of the air gap, and reflection inside the patch to obtain a “bulb-like” illumination, guiding the light towards the target tissue. Large area, high intensity, wide spectrum, continuous/pulsatile, deeply penetrating illumination was achieved without puncturing the target tissues. ICarP supported phototherapies with different photosensitizers and achieved higher efficacy compared to optical fibers with clinically relevant optical fiber structures, attributed to the light scattering effect. The robust photonic device is compatible with thoracoscopy-based minimally invasive implantation and exhibited consistent performance on mechanically dynamic animal hearts in a demonstrative application of in situ photosynthesis for myocardial infarction treatment. The iCarP phototherapy improved survival of cardiac cells and preserved cardiac functions. These initial results showed that iCarP could be a safe, precise and widely applicable device suitable for internal organs/tissues illumination and associated therapy and diagnosis.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE223691 | GEO | 2023/04/23

REPOSITORIES: GEO

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Project description:Tikidji-Hamburyan2018 - Rod phototransduction under strong illumination This model is described in the article: Rods progressively escape saturation to drive visual responses in daylight conditions. Tikidji-Hamburyan A, Reinhard K, Storchi R, Dietter J, Seitter H, Davis KE, Idrees S, Mutter M, Walmsley L, Bedford RA, Ueffing M, Ala-Laurila P, Brown TM, Lucas RJ, Münch TA. Nat Commun 2017 Nov; 8(1): 1813 Abstract: Rod and cone photoreceptors support vision across large light intensity ranges. Rods, active under dim illumination, are thought to saturate at higher (photopic) irradiances. The extent of rod saturation is not well defined; some studies report rod activity well into the photopic range. Using electrophysiological recordings from retina and dorsal lateral geniculate nucleus of cone-deficient and visually intact mice, we describe stimulus and physiological factors that influence photopic rod-driven responses. We find that rod contrast sensitivity is initially strongly reduced at high irradiances, but progressively recovers to allow responses to moderate contrast stimuli. Surprisingly, rods recover faster at higher light levels. A model of rod phototransduction suggests that phototransduction gain adjustments and bleaching adaptation underlie rod recovery. Consistently, exogenous chromophore reduces rod responses at bright background. Thus, bleaching adaptation renders mouse rods responsive to modest contrast at any irradiance. Paradoxically, raising irradiance across the photopic range increases the robustness of rod responses. This model is hosted on BioModels Database and identified by: MODEL1710030000. To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

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A biodegradable, flexible photonic patch for in vivo phototherapy

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