Dataset Information


CGH profiles of primary breast carcinomas from HBOC (Hereditary Breast and Ovarian Cancer) families

ABSTRACT: 89 tumors from women that were eligible for, and subjected to, routine diagnostic testing according to the HBOC criteria but were negative for pathogenic BRCA1/2-mutations or carried an UV in either BRCA1/2 Overall design: A BRCA2-classifier was built using array-CGH profiles of 28 BRCA2-mutated and 28 sporadic breast tumors. The classifier was validated on an independent group of 19 BRCA2-mutated and 19 sporadic breast tumors. Subsequently, we tested 89 breast tumors from suspected hereditary breast (and ovarian) cancer (HBOC) families, in which either no BRCA1/2 mutation or an UV had been found by routine diagnostics.

INSTRUMENT(S): Netherlands Cancer Institute human 3.5k BAC array

ORGANISM(S): Homo sapiens  

SUBMITTER: Simon A Joosse  

PROVIDER: GSE22481 | GEO | 2010-07-05



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