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Effect of meiosis specific cohesin subunit SMC1 on chromatin architecture in primary murine spermatocytes [ATAC-Seq]

ABSTRACT: To investigate the function of meiosis-specific SMC1beta on chromatin architecture near the telomeric end in primary murine spermatocytes we used a SMC1beta knockout mouse model.

ORGANISM(S): Mus musculus

PROVIDER: GSE230553 | GEO | 2023/05/04

REPOSITORIES: GEO

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Effect of meiosis specific cohesin subunit SMC1 on chromatin architecture in primary murine spermatocytes [RNA-Seq 2]

Project description:To investigate the function of meiosis-specific SMC1beta on chromatin architecture near the telomeric end in primary murine spermatocytes we used a SMC1beta knockout mouse model.

2023-05-04 | GSE230555 | GEO

Effect of meiosis specific cohesin subunit SMC1 on chromatin architecture in primary murine spermatocytes [RNA-Seq 1]

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Effect of meiosis specific cohesin subunit SMC1 on chromatin architecture in primary murine spermatocytes

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Effect of meiosis specific cohesin subunit SMC1 on chromatin architecture in primary murine spermatocytes

Project description:This SuperSeries is composed of the SubSeries listed below.

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Effect of meiosis specific cohesin subunit SMC1 on chromatin architecture in primary murine spermatocytes [RNA-Seq 1]

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Effect of meiosis specific cohesin subunit SMC1 on chromatin architecture in primary murine spermatocytes [RNA-Seq 2]

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Project description:Protein phosphorylation, as one of the most important post-translational modifications, exerts crucial roles in regulating meiosis. However, there is a lack of systemic phosphoproteomic and functional analysis of phosphorylation in the meiosis of spermatocytes. To characterize the phosphorylation events in meiosis, we performed large-scale phosphoproteome profiling of purified spermatocytes undergoing meiosis, and identified 20,582 phosphorylation sites in 5,289 phosphoproteins, which were significantly enriched in cell cycle, autophagy, DNA repair, chromosome segregation. Kinase-substrate phosphorylation network analysis followed by in vitro meiosis study showed that CDK9 was a kinase with enriched substrate phosphorylation sites in spermatocytes, and was essential for meiosis progression to metaphase I. We also identified 15 new phosphorylation sites of histones, and 428 epigenetic factors, among which HASPIN was found to be essential for male fertility. Haspin knockout leaded to misalignment of chromosomes, apoptosis of metaphase spermatocytes and decreased number of sperm by deregulation of H3T3ph and Aurora-B kinase-containing chromosomal passenger complex. Our spermatocyte phosphoproteome will be a rich resource for future studies of phosphorylation signaling regulation of meiosis.

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Cohesin subunit SMC1 associates with mitotic microtubules at the spindle pole.

Project description:Accurate mitotic chromosome segregation depends on the formation of a microtubule-based bipolar spindle apparatus. We report that the cohesin subunit structural maintenance of chromosomes subunit 1 (SMC1) is recruited to microtubule-bound RNA export factor 1 (Rae1) at the mitotic spindle pole. We locate the Rae1-binding site to a 21-residue-long region, SMC1(947-967) and provide several lines of evidence that phosphorylation of Ser(957) and Ser(966) of SMC1 stimulates binding to Rae1. Imbalances in these assembly pathways caused formation of multipolar spindles. Our data suggest that cohesin's known bundling function for chromatids in mitotic and interphase cells extends to microtubules at the spindle pole.

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