Genomics

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Gene expression data of APC-mutated colorectal cancer patient-derived cells treated with tankyrase inhibitors


ABSTRACT: Tankyrase, a poly(ADP-ribose) polymerase family member, regulates multiple cellular processes. Tankyrase inhibitors efficiently suppress APC-mutated colorectal cancer (CRC) cell proliferation. To examine the mechanism of anti-proliferative effect of tankyrase inhibitors (G007LK and RK582), we analyzed gene expression profiles of patient-derived APC-mutated CRC cells (JC21 and JC475) left untreated or treated with 0.3 µM G007LK or RK582 for 24 h by cDNA microarray analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE232209 | GEO | 2024/01/17

REPOSITORIES: GEO

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