Genomics

Dataset Information

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Expression data of colon cancer COLO320DM cells and tankyrase inhibitor-resistant variant 320-IWR cells


ABSTRACT: Wnt/β-catenin signaling is activated in colorectal cancer (CRC) and is involved in CRC growth. Tankyrase, a poly(ADP-ribose) polymerase family member, destabilizes Axin and positively regulates the Wnt/β-catenin signaling. Tankyrase inhibitors efficiently suppress CRC cell proliferation. We established 320-IWR cells, which showed resistance to tankyrase inhibitor IWR-1, from human CRC COLO-320DM cells. We analyzed gene expression profile of 320-IWR cells (320IWR_1,_2) and parental COLO-320DM cells (COLO320_1,_2).

ORGANISM(S): Homo sapiens

PROVIDER: GSE86061 | GEO | 2016/11/01

SECONDARY ACCESSION(S): PRJNA340149

REPOSITORIES: GEO

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