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Impact of Conditional Knockout of Complement C3 and Sphingosine-1-Phosphate Receptor 1 (S1PR1) on Lung Metastasis in MMTV-PyMT Mice

ABSTRACT: Recent evidence suggests that sphingosine-1-phosphate receptor 1 (S1PR1) modulates the intracellular complement system or the complosome to induce NLRP3 inflammasome formation and the release of IL-1β through caspase-1, thereby promoting tumor metastasis. Here, we examined the transcriptomic effects of S1PR1 and complement C3 conditional knockouts on lung metastasis in MMTV-PyMT Mice, a widely used model for studying mammary tumor progression and metastasis.

ORGANISM(S): Mus musculus

PROVIDER: GSE235593 | GEO | 2026/06/19

REPOSITORIES: GEO

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Gene expression profiles of peritoneal macrophages from Sphingosine 1-phosphate receptor type 1 (S1pr1) overexpressing mice against control mice.

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Project description:S1PR1 Overexpression cells activates endogenous complement signaling and inflammasome to induce tumor metastasis in mice

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