Transcriptomics

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Transcriptional profiling of tumor microenvironment in B2M KO CD40-treated B16 tumors implanted in mice


ABSTRACT: The immune changes induced by loss of antigen presentation by tumor cells, a common mechanism of acquired resistance to immunotherapy, as well as the mechanisms by which CD40 agonist treatment controls the growth of B2m-null tumors, are unknown. We performed single-cell RNA-seq of total tumor-infiltrating immune cells in control and B2m-null tumors treated with isotype control or CD40 agonist antibodies to identify changes in immune cell states due to tumor cell loss of B2m and agonist CD40 treatment.

ORGANISM(S): Mus musculus

PROVIDER: GSE240148 | GEO | 2026/02/02

REPOSITORIES: GEO

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