The intestinal microbiota modulates the transcriptional landscapes of iNKT cells
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ABSTRACT: Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to microbe-derived glycolipid antigens. Our previous work suggested that the gut microbiota influenced iNKT cell functions during dextran sulfate sodium-induced colitis in mice. In this study, we showed that prenatal fecal transplant of different microbial community in specific pathogen-free mice led to transcriptional alterations in iNKT cells at steady state and following aGC-mediated activation in the offspring. In addition, iNKT cell transcriptional signatures also differed between male and female mice. Collectively, our findings suggest that sex and the intestinal microbiota are important factors that regulate iNKT cell homeostasis and responses.
ORGANISM(S): Mus musculus
PROVIDER: GSE242752 | GEO | 2024/03/14
REPOSITORIES: GEO
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