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C/EBP⍺ Aggravated Ferroptosis and Apoptosis in Renal Tubular Epithelial Cell

ABSTRACT: Acute Kidney Injury (AKI) is widely recognized for its rapid deterioration in renal function, often resulting in unfavorable clinical outcomes. An increase in the expression of CCAAT/enhancer binding protein alpha (C/EBP⍺) has been observed in both human and mouse kidneys affected by AKI. We unraveled the downstream pathway of C/EBP⍺ through RNA-sequencing, confirming our findings with qRT-PCR and luciferase reporter assays. Furthermore, we identified a potential target for AKI reversal in a murine AKI model.

ORGANISM(S): Homo sapiens

PROVIDER: GSE242804 | GEO | 2023/09/14

REPOSITORIES: GEO

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