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Mitotic endosomes regulate spindle organization and function via Occludin and FIP5 binding

ABSTRACT: The genetic basis of vertebrate emergence is a major unanswered question in metazoan evolution. Understanding vertebrate-specific genes, such as Occludin (Ocln), may help answer this question. Here, we show that mammary glands lacking Ocln exhibit retarded branching, resulting from reduced cell proliferation. Interestingly, Ocln regulates spindle orientation and function, and its loss leads to a range of phenotypes, including prolonged prophase and failed nuclear and/or cytoplasmic division.

ORGANISM(S): Mus musculus

PROVIDER: GSE242842 | GEO | 2025/09/11

REPOSITORIES: GEO

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Epididymal epithelial degeneration and lipid metabolism impairment account for male infertility in occludin knockout mice

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Mitotic endosomes regulate spindle organization and function via Occludin and FIP5 binding

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Epididymal epithelial degeneration and lipid metabolism impairment account for male infertility in occludin knockout mice

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Tight Junction Component Occludin Binds to FIP5 to Regulate Endosome Trafficking and Mitotic Spindle Function.

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