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Effect of polyIC administration on gene expression in decidual tissues of E13.5 mice

ABSTRACT: Previous research indicate that maternal immune activation (MIA) correlated with increased frequency of autism spectrum disorder (ASD) in offspring. Our data sugests that aberrant decidual NK cells are required for MIA-induced neurodevelopment and behavioral disorders. To determine what triggers dNK cells to react to MIA at the maternal-fetal interface, we evaluated the DEGs of decidua tissue samples from dams triggered with polyIC or saline control.

ORGANISM(S): Mus musculus

PROVIDER: GSE244114 | GEO | 2025/08/01

REPOSITORIES: GEO

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Effect of polyIC administration on gene expression in decidual NK cells of E13.5 mice

Project description:Previous research indicate that maternal immune activation (MIA) correlated with increased frequency of autism spectrum disorder (ASD) in offspring. Our data sugests that maternal NK cells facilitate MIA-induced neurodevelopment and behavioral disorders. To determine how aberrant maternal NK cells instruct the developmental trajectory of the fetal brain environment, we evaluated the DEGs of decidua NK cells from dams triggered with polyIC or saline control.

2025-08-01 | GSE244115 | GEO

Single-cell RNA-seq to decipher the subpopulations of human decidual leukocytes in normal and RSA pregnancies

Project description:Maternal fetal immune tolerance is a biological event that plays a key role in pregnancy. In particular, the mechanism by which the maternal immune system does not exclude the semi-identical antigen of the fetus has not been fully answered so far. The most serious result of the maternal fetal immune tolerance balance is the recurrent spontaneous abortion (RSA). The fetus is rejected by the mother in the early pregnancy and cannot continue to develop in the uterus. Based on these scientific questions, we used single-cell sequencing technology to analyze nearly 30,000 leukocytes in the decidua of normal and RSA. A total of 13 immune cell subsets were found, of which dNK cells were more prominent, The lineage differentiation pathway of dNK cells was excavated, and the pathological role of dNK differentiation abnormality in the occurrence of RSA was analyzed. Our results deepen our understanding of the differentiation and function of human decidual leukocytes, especially dNK cells. We clearly recognize that the immune system has dynamic changes compared with normal pregnancy under pathological conditions, which is likely to occur in RSA. The important factors, we expect our results to provide a new basis for RSA's immune diagnosis and treatment strategy.

2021-07-20 | GSE130560 | GEO

Effect of polyIC administration on gene expression in decidual tissues of E13.5 mice

Project description:Effect of polyIC administration on gene expression in decidual tissues of E13.5 mice

| PRJNA1021249 | ENA

Multiomic analysis reveals decidual-specific transcriptional programing of MAIT cells

Project description:Problem: Mucosal-Associated Invariant T (MAIT) cells have been recently identified at the maternal-fetal interface. However, transcriptional programming of decidual MAIT cells in pregnancy remains poorly understood. Method of Study: We employed a multiomic approach to address this question. Mononuclear cells from the decidua basalis and parietalis, and control PBMCs, were analyzed via flow cytometry to investigate MAIT cells in the decidua and assess their transcription factor expression. In a separate study, both decidual and matched peripheral MAIT cells were analyzed using Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq) coupled with gene expression analysis. Lastly, decidual MAIT cells were stimulated with E. coli and expression of MR1 by antigen presenting cells was measured to evaluate decidual MAIT cell function. Results: First, we identified MAIT cells in both the decidua basalis and parietalis. CITE-seq, coupled with scRNAseq gene expression analysis, highlighted transcriptional programming differences between decidual and matched peripheral MAIT cells at a single cell resolution. Transcription factor expression analysis further highlighted transcriptional differences between decidual MAIT cells and non-matched peripheral MAIT cells. Functionally, MAIT cells are skewed towards IFNg and TNFa production upon stimulation, with E. coli leading to IFNg production. Lastly, we demonstrate that MR1, the antigen presenting molecule restricting MAIT cells, is expressed by decidual APCs. Conclusion: MAIT cells are present in the decidua basalis and obtain a unique gene expression profile. The presence of MR1 on APCs coupled with in vitro activation by E. coli suggests that MAIT cells might be involved in tissue-repair mechanisms at the maternal-fetal interface.

2021-09-07 | GSE183421 | GEO

Effect of polyIC administration on gene expression in decidual NK cells of E13.5 mice

Project description:Effect of polyIC administration on gene expression in decidual NK cells of E13.5 mice

| PRJNA1021252 | ENA

Decidual NK cells Xiong et al 2013

Project description:Receptors of the KIR family on maternal Natural Killer cells in the decidua are believed to bind to Ligands such as HLA-C on trophoblast cells invading into the decidua from the placenta during early pregnancy. The resulting responses regulate the extent of trophoblast invasion. Genetic studies have implicated two members of the KIR family in particular as playing an important role: KIR2DL1 and KIR2DS1. The aim of this experiment was to determine what responses are generated when decidual NK cells bearing either KIR2DL1 or KIR2DS1 engage their HLA-C ligand.

2014-04-04 | E-MTAB-1784 | biostudies-arrayexpress

Granulysin-high decidual NK cells in macaques and humans share signatures of immune defense and regulation

Project description:Decidual NK cells (dNK) are key immune effector cells at the maternal-fetal interface. dNK utilize the anti-microbial peptide granulysin (GNLY) to kill pathogens, without killing trophoblast cells. Since rodents lack the GNLY gene, the in vivo biology of GNLY expression by dNK and their control of microbes is not well-understood. Here we defined dNK GNLY expression in placental membranes of Rhesus macaques and humans. GNLY-high dNK of both species shared conserved transcriptional and protein signatures of anti-microbial defense and immunoregulation. In addition, both human and rhesus GNLY-high dNK responded to inflammation and infection by increasing their cytotoxic, cytokine and inflammatory signatures. Thus high GNLY expression defines a unique dNK type with active roles in innate immune defense in humans and Rhesus macaques. Defining the regulatory networks of GNLY expression by dNK and their mechanism of infection control will open up therapeutic opportunities to enhance immunity and reduce infection-related pregnancy complications

2025-04-01 | GSE282837 | GEO

CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy

Project description:Regulatory T cells (Tregs) play crucial roles in maintaining maternal immune tolerance to the semi-allogeneic fetus during pregnancy, but Treg population heterogeneity and tissue-specific functions in human decidua remain largely unknown. Here, we conducted single-cell transcriptomic and T cell receptor sequencing of CD4+ T cells from first-trimester decidua and matched peripheral blood of pregnant women. These analyses identified a highly activated, immunosuppressive CCR8+ Treg subset specifically enriched in decidua (dTregs). CCR8+ dTregs are decreased in recurrent pregnancy loss (RPL) patients and abortion-prone model mice. Depletion of this subset with anti-CCR8 antibodies alters the decidual immune profile, increasing susceptibility to fetal loss. The CCR8 ligand, CCL1, is mainly produced by decidual CD49a+ NK cells and is also significantly decreased in RPL patients. By characterizing the landscape of dTregs in human early pregnancy, we identified CCR8+ dTregs as crucial for maintaining maternal-fetal tolerance, suggesting new potential strategies for RPL diagnosis and therapy.

2025-04-15 | GSE252187 | GEO

Expression data of human decidual NK cells from gravid uteri and NK cells from cycling endometrium

Project description:Human NK cells from the decidua basalis of gravid uteri (dNK) and from cycling endometrium (eNK) of women undergoing hysterectomy were isolated and compared by gene expression profiling using Affymetrix microarrays with probes representing ~47,400 transcripts. Substantial differences indicate that these two types of NK cells represent distinct subsets. Freshly isolated NK cells were obtained by FACS sorting. 4 dNK and 5 eNK samples were obtained form independent donors. dNK cells were isolated from the decidua basalis of first trimester placentas and sorted as CD3-, CD16-, CD56+ cells. eNK cells were obtained from non-affected regions of cycling endometrium of donor women undergoing hysterectomy and were sorted as CD45+, CD56+, CD3- cells . The preliminary patient diagnoses included genital prolapse, fibroids, cervical dysplasia, or menorrhagia. All cycling endometrium samples were from the secretory phase of the cycle with exception of sample eNK_S6 that was from the proliferative phase.

2010-03-09 | E-GEOD-20499 | biostudies-arrayexpress

The role of chorionic PGRMC2 and HLA-G in maintaining immune homeostasis at the chorio-decidual interface

Project description:The chorio-decidual interface (CDi) is formed by chorion trophoblasts (CTCs) and immune cell-rich decidua (DECs) cells. The roles of human leukocyte antigen (HLA)-G and progesterone receptor membrane component 2 (PGRMC2) in mediating innate immune homeostasis at this maternal-fetal interface interface were investigated.

2024-01-02 | GSE251809 | GEO

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