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Effect of polyIC administration on gene expression in decidual NK cells of E13.5 mice

ABSTRACT: Previous research indicate that maternal immune activation (MIA) correlated with increased frequency of autism spectrum disorder (ASD) in offspring. Our data sugests that maternal NK cells facilitate MIA-induced neurodevelopment and behavioral disorders. To determine how aberrant maternal NK cells instruct the developmental trajectory of the fetal brain environment, we evaluated the DEGs of decidua NK cells from dams triggered with polyIC or saline control.

ORGANISM(S): Mus musculus

PROVIDER: GSE244115 | GEO | 2025/08/01

REPOSITORIES: GEO

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Effect of polyIC administration on gene expression in decidual tissues of E13.5 mice

Project description:Previous research indicate that maternal immune activation (MIA) correlated with increased frequency of autism spectrum disorder (ASD) in offspring. Our data sugests that aberrant decidual NK cells are required for MIA-induced neurodevelopment and behavioral disorders. To determine what triggers dNK cells to react to MIA at the maternal-fetal interface, we evaluated the DEGs of decidua tissue samples from dams triggered with polyIC or saline control.

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