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Antioxidant program of islet-resident macrophages preserves β cell physiology

ABSTRACT: Macrophages residing inside mouse pancreatic islets have an activated phenotype at steady-state. To explore the molecular pathways involved in their polarization, we compared the transcriptomic signatures of islet-resident macrophages with autologous epididymal adipose tissue (EpiWAT)-resident macrophages. Our data confirmed the pro-inflammatory profile of islet marophages and revealed also strong anti-oxidant capacities compared to EpiWATcells.

ORGANISM(S): Mus musculus

PROVIDER: GSE246999 | GEO | 2025/11/17

REPOSITORIES: GEO

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Antioxidant program of islet-resident macrophages preserves β cell physiology

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