Expression data from mouse ovarian surface epithelium cells at different stages of malignancy

ABSTRACT: Ovarian cancer is one of the most deadly cancers accounting for only 3% of diagnosed cancers, but is the fifth leading cause of cancer deaths among woman; however, the progression of ovarian cancer is poorly understood. To study and further understand the early events that lead to epithelial derived ovarian cancer, we previously developed a cell model of progressive ovarian cancer. Mouse ovarian surface epithelial (MOSE) cells have undergone spontaneous transformation in cell culture and represent pre-neoplastic, non-tumorigenic to an aggressive malignant phenotype. Microarray analysis was performed with RNA isolated from different stages of MOSE cells to examine changes in gene expression as MOSE cells transition from a pre-neoplastic to a malignant state.

ORGANISM(S): Mus musculus

PROVIDER: GSE24789 | GEO | 2011/03/03

SECONDARY ACCESSION(S): PRJNA132243

REPOSITORIES: GEO