Understanding the mechanisms of resistance to BRAF inhibitors in colorectal cancer

ABSTRACT: Mutations in proto-oncogene BRAF occur in about 10-15% of CRC patients and BRAFV600E is the most common. Most patients with BRAFV600E metastatic CRC show reduced survival compared to patients with wild-type BRAF. For patients who undergo BRAF-targeted therapy, resistance develops 4-6 months after treatment initiation and results in more aggressive disease. We established PT130 cells resistant to PLX8394, a novel BRAF inhibotor, and tested them in vitro and in vivo.

ORGANISM(S): Homo sapiens

PROVIDER: GSE248414 | GEO | 2025/09/01

REPOSITORIES: GEO