Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The effect of glutamine on EMT and lung cancer metastasis

ABSTRACT: To investigate the effect of glutamine on lung cancer cell EMT and metastasis, we used TGFbeta to treat A549 cells for 24 hours, which were cultured under glutamine depletion or 0.2 mM or 0.5 mM glutamine. RNA-seq was performed to analyze the EMT signature of A549 cells with or without glutamine.

ORGANISM(S): Homo sapiens

PROVIDER: GSE249357 | GEO | 2026/06/05

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer [mouse]

Project description:Tumor cells rely on glutamine to fulfill their metabolic demands and sustain proliferation. The elevated consumption of glutamine can lead to intratumoral nutrient depletion, causing metabolic stress that has the potential to impact tumor progression. Here, we show that nutrient stress caused by glutamine deprivation leads to the induction of epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) cells. Mechanistically, we demonstrate that glutamine deficiency regulates EMT through the upregulation of the EMT master regulator Slug, a process that is dependent on both MEK/ERK signaling and ATF4. We find that Slug is required in PDAC cells for glutamine deprivation-induced EMT, cell motility and nutrient stress survival. Importantly, we decipher that Slug is associated with nutrient stress in PDAC tumors and is required for metastasis. These results delineate a novel role for Slug in the nutrient stress response and provide insight into how nutrient depletion might influence PDAC progression.

2020-05-20 | GSE150874 | GEO

Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer [human]

2020-05-20 | GSE150873 | GEO

Differential gene expression studies in a TGF beta induced EMT model of lung cancer A549 cell lines

Project description:Investigate the difference in gene expression in TGFbeta induced EMT in lung cancer cell line A549 in comparison to uninduced A549 cells.

2023-02-09 | GSE224631 | GEO

The effect of glutamine on EMT and lung cancer metastasis

Project description:The effect of glutamine on EMT and lung cancer metastasis

| PRJNA1048850 | ENA

Glutamine Links Obesity to Inflammation in Human White Adipose Tissue [array]

Project description:SP1-regulated transcriptome: Gene expression microarray following SP1 RNAi to define the SP1-regulated transcriptome in human in vitro differentiated adipocyte. Glutamine-regulated transcriptome: Gene expression microarray in human in vitro differentiated adipocyte incubated in high (10 mM) and low (0.5 mM) concentrations of glutamine.

2019-11-15 | GSE140424 | GEO

Glutamine Links Obesity to Inflammation in Human White Adipose Tissue [ChIP-seq]

Project description:Mapping of O-GlcNAcylated proteome along the genome by chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) in in vitro differentiated human adipocytes incubated with low (0.5 mM) or high (10 mM) glutamine.

2019-11-15 | GSE140425 | GEO

Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer

Project description:Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer

| PRJNA633897 | ENA

Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer [human]

Project description:Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer [human]

| PRJNA633899 | ENA

Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer [mouse]

Project description:Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer [mouse]

| PRJNA633900 | ENA

The dual role of Irf1 in maintaining epithelial identity while enabling EMT [mRNA-seq]

Project description:To investigate the context-dependent function of Irf1 in maintaining epithelial identity while enabling TGFbeta-induced EMT in NMuMG/E9 cells, we downregulated Irf1 by siRNA and analyzed differentially regulated genes and pathways upon EMT induction (2 days TGFbeta) or in the absence of EMT (0 day TGFbeta). Intersection with Irf1 ChIP-sequencing after 2 days of TGFbeta treatment or in untreated cells revealed genes that are directly regulated by Irf1 and that could contribute to the dual role of Irf1 in EMT.

2022-03-18 | GSE141500 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data