Transcriptomics

Dataset Information

0

Exosomal miR-92a-3p as a diagnostic biomarker for adenomyosis and its pathological mechanism


ABSTRACT: This study aimed to elucidate the role of microRNA miR-92a-3p in the pathogenesis of adenomyosis. We focused on understanding how miR-92a-3p in exosomes derived from ectopic lesions influences the behavior of endometrial cells, DRG neurons, and Human Umbilical Vein Endothelial Cells (HUVECs), and its potential as a non-invasive diagnostic biomarker. Our findings revealed that MiR-92a-3p is significantly upregulated in exosomes derived from ectopic lesions of adenomyosis. This upregulation was associated with enhanced migration and invasion capabilities in eutopic endometrial cells, DRG neurons, and HUVECs. Furthermore, the study demonstrated a significant correlation between the levels of MiR-92a-3p in urinary exosomes and the clinical symptoms of adenomyosis, suggesting its potential as a non-invasive biomarker for the disease. This study elucidates an exosomal signaling process via miR-92a-3p that drives pathological infiltration and angiogenesis to promote adenomyosis progression. Upregulated miR-92a-3p in biofluid exosomes shows promising non-invasive biomarker potential for diagnosis and monitoring of this disease. Our findings unveil novel targets and tools for improved clinical management.

ORGANISM(S): Homo sapiens

PROVIDER: GSE262302 | GEO | 2024/04/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-07-01 | E-MTAB-8093 | biostudies-arrayexpress
2022-01-01 | GSE166799 | GEO
2015-10-28 | E-GEOD-74373 | biostudies-arrayexpress
2015-10-28 | GSE74373 | GEO
2022-09-28 | GSE214170 | GEO
2022-09-15 | GSE176159 | GEO
2019-03-01 | GSE120038 | GEO
2022-02-19 | GSE190515 | GEO
2012-06-01 | GSE35794 | GEO
2017-03-29 | MSV000080762 | MassIVE