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Positive emotion-specific changes in gene expression profile in brain and peripheral tissues of the tickled rats

ABSTRACT: The changes of mRNA expression levels were analyzed in striatum, salivary glands , and peripheral leukocyte of the juvenile rat stimulated by tickling for 4 weeks as a positive stimulation. Keywords: Stress response Overall design: Twenty-one-day-old male Wistar rats after weaning were used. All rats were separately maintained in the standard cages which were shielded with screens not to see each other during the study. The rats were then subjected to the following three conditions; tickling, light touch, and no stimulus. The stimulation was given to the rats once every weekday (Monday to Friday) for 4 weeks. Tickling stimulation was used as a mimic of the rough-and-tumble play of rats which induced a positive emotional response [50 kHz ultrasonic vocalization (USV)]. Light touch was a discriminative stimulation to tickling, and neither the rat with light touch nor with no stimulus showed such a response in general. Gene expression changes in striatum, salivary glands, and peripheral leukocyte of the tickled rats were comprehensively analyzed comparing with light touched and no stimulated rats using microarray techniques. Biological replicates: 4 animals each condition. One replicate per array.

INSTRUMENT(S): Agilent-013162 Whole Rat Genome Microarray G4131A (Feature Number version)

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Katsuyuki Hayashi   




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