Transcriptomics

Dataset Information

26

Upregulation of pro-apoptotic microRNA mir-125a following massive small bowel resection in rats


ABSTRACT: Upregulation of mir-125a suppresses the pro-survival protein Mcl1, producing the increase in apoptosis known to accompany the proliferative changes characteristic of intestinal adaptation. Our data highlight a potential role for microRNAs as mediators of the adaptive process and may facilitate the development of new therapeutic options for short bowel syndrome. Overall design: Two-condition experiment: resected rat jejunum vs. pooled transected control, with dye-swaps.

INSTRUMENT(S): Exiqon miRCURY LNA microRNA array v.8.1

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Jonathan M Dreyfuss 

PROVIDER: GSE26542 | GEO | 2012-05-03

SECONDARY ACCESSION(S): PRJNA136619

REPOSITORIES: GEO

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