Transcriptomics

Dataset Information

33

An antioxidant response phenotype is shared between hereditary and sporadic type 2 papillary renal cell carcinoma


ABSTRACT: Fumarate hydratase (FH) mutation causes hereditary type 2 papillary renal cell carcinoma (HLRCC, Hereditary Leiomyomatosis and Renal Cell Cancer (MM ID # 605839)). The main effect of FH mutation is fumarate accumulation. The current paradigm posits that the main consequence of fumarate accumulation is HIF-a stabilization. Paradoxically, FH mutation differs from other HIF-a stabilizing mutations, such as VHL and SDH mutations, in its associated tumor types. We identified that fumarate can directly up-regulate antioxidant response element (ARE)-controlled genes. We demonstrated that AKR1B10 is an ARE-controlled gene and is up-regulated upon FH knockdown as well as in FH-null cell lines. AKR1B10 overexpression is also a prominent feature in both hereditary and sporadic PRCC2. This phenotype better explains the similarities between hereditary and sporadic PRCC2. Overall design: Expression profiling renal normal and tumor tissue

INSTRUMENT(S): Affymetrix Human Genome U133 Plus 2.0 Array [MBNI v9 Entrez Gene ID CDF]

ORGANISM(S): Homo sapiens  

SUBMITTER: Karl Dykema 

PROVIDER: GSE26574 | GEO | 2011-10-18

SECONDARY ACCESSION(S): PRJNA136247

REPOSITORIES: GEO

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