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Spatiotemporal multi-omics analysis reveals distinct epigenetic and transcriptional signatures in the hippocampal-amygdala circuit during fear memory consolidation [CFC_Spatial]

ABSTRACT: The consolidation of contextual fear memories requires the crosstalk among multiple brain regions, including the hippocampus and amygdala. Despite the advance in single cell transcriptomic techniques, tracing the dynamic gene expression across the hippocampal-amygdala circuit remain challenging. Here we integrated high resolution spatial transcriptomics with single nuclei multi-omics techniques to systematically investigate the spatiotemporally transcriptional programs across the hippocampal-amygdala circuit during the encoding and retrieval of contextual fear memory. It reveals highly dynamic gene expression in the subregions of hippocampus and amygdala. Our data provide new insights into the transcriptional programs underlying consolidation of memory.

ORGANISM(S): Mus musculus

PROVIDER: GSE267138 | GEO | 2025/07/05

REPOSITORIES: GEO

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Spatiotemporal multi-omics analysis reveals distinct epigenetic and transcriptional signatures in the hippocampal-amygdala circuit during fear memory consolidation [CFC_Spatial]

Project description:Spatiotemporal multi-omics analysis reveals distinct epigenetic and transcriptional signatures in the hippocampal-amygdala circuit during fear memory consolidation [CFC_Spatial]

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