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Transcriptomics analysis of white adipose tissue, gastrocnemius muscle and liver tissues from Ogg1Tg mice.

ABSTRACT: Obesity is associated with increased oxidative stress that damages genomic and mitochondrial DNA. Oxidatively-induced lesions in both DNA pools are repaired via the base-excision repair pathway, initiated by DNA glycosylases such as 8-oxoguanine DNA glycosylase (OGG1). Global deletion of OGG1 and common OGG1 polymorphisms render mice and humans susceptible to metabolic disease. Moreover, mice with transgenic targeting of OGG1 to mitochondria (Ogg1Tg mice) confer significant protection from diet-induced obesity, insulin resistance, and adipose tissue inflammation. Here, we analyzed transcriptomics of gastrocnemius muscle from Ogg1Tg mice and control mice (C57BL/6J mice) by bulk RNA sequencing (RNAseq).

ORGANISM(S): Mus musculus

PROVIDER: GSE267211 | GEO | 2026/04/15

REPOSITORIES: GEO

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