RNA-seq in EndoCbetaH5 under high glucose, treated or not with naltrindole

ABSTRACT: In human EndoCβH5 cells, i.e. post-mitotic mature pancreatic beta cells that endogenously express OPRD1 encoding delta opioid receptor (transcripts per million [TPM] of 11 according to our RNA-seq data), a specific antagonist for delta opioid receptor (naltrindole [NTI]) significantly increased insulin secretion in high glucose condition. We performed RNA-seq in these cells to decipher signalling pathways under delta opioid receptor antagonism.

ORGANISM(S): Homo sapiens

PROVIDER: GSE271922 | GEO | 2024/07/10

REPOSITORIES: GEO