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Investigating the Impact of Genetic MSN Depletion on Gene Expression in MDA-MB-231 Breast Cancer Cells

ABSTRACT: Cellular differentiation is a tightly regulated process, relying on the precise interplay between lineage-specific transcription factors and epigenetic modifications to both initiate and sustain distinct cell fates. Here, we report Moesin as a key regulator of tumor growth and metastasis in the MDA-MB-231 breast cancer cell line. MSN, a linker between the actin cytoskeleton and the plasma membrane, regulates cell morphology and motility. Our results demonstrate that MSN depletion impairs microtubule cytoskeleton organization and microtubule polymerization. Furthermore, we observed elevated MSN levels in Triple-Negative Breast Cancer cells, which exhibit aggressive growth characteristics. Taken together, our data reveal a crucial role for MSN in mediating tumor growth and metastasis, thereby contributing to the aggressiveness of breast cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE272103 | GEO | 2025/07/30

REPOSITORIES: GEO

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