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ScRNA-seq of human cerebral organoids derived from healthy and FOXG1 syndrome patients iPSCs at d105

ABSTRACT: Disruptions in gene expression programs during nervous system development?affecting both transcriptional and post-transcriptional regulation?are implicated in a range of neurodevelopmental disorders. Among these, FOXG1 syndrome remains poorly understood, particularly with respect to the mechanistic role of its namesake gene, FOXG1. In this study, we performed single-cell RNA sequencing (scRNA-seq) on day 105 (d105) cerebral organoids derived from healthy controls as well as from iPSCs carrying FOXG1^del and FOXG1^c.460dupG mutations, to investigate cell type?specific gene expression changes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE273180 | GEO | 2025/05/21

REPOSITORIES: GEO

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