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Single-cell transcriptomic comparison of young and aged dermal macrophages

ABSTRACT: Previously, in a meta-analysis of public single-cell transcriptomes profiling various healthy and disease tissues, we demonstrated that macrophage heterogeneity in skin, as well as in other mouse tissues, could be described into 5 distinct identities (S1-5) with a defined transcriptomic fingerprint, regardless of tissue origins. We established a general identity scheme for tissue macrophages, MIKA (Macrophage Identity Kinetics Archive) as an alternative to the conventional M1/M2 scheme which shows limitations in annotating in vivo tissue macrophages. (PMID: 39720957) MIKA was recently updated to finetune identity definition, and to include more tissues and pathophysiological conditions. (PMID: 41342690) Under the current MIKA framework, tissue macrophages are classified to 6 core identities (S1-S6, common to various tissues) and/or tissue-specific macrophages. This dataset is a part of the raw data sources of the latest version of MIKA profiling single-cell transcriptomes of F4/80+MHCII-hi macrophages FACS-isolated from dorsal skin of young (9 week-old) and old (108 week-old) C57BL/6 male mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE275826 | GEO | 2025/12/07

REPOSITORIES: GEO

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