Transcriptomics

Dataset Information

0

CSF1-R inhibition attenuates posttraumatic osteoarthritis and quadriceps atrophy following ligament injury II


ABSTRACT: Knee osteoarthritis contributes substantially to worldwide disability. Post-traumatic osteoarthritis (PTOA) develops secondary to a joint injury, such as ligament rupture, and there is increasing evidence suggesting a key role for inflammation in the etiology of PTOA and associated functional deficits. Colony stimulating factor 1 receptor (CSF1-R) has been implicated in the pathogenesis of musculoskeletal degeneration following anterior cruciate ligament (ACL) injury. We sought to assess the efficacy CSF1-R inhibition to mitigate muscle and joint pathology in a mouse model of PTOA. Four-month-old mice were randomized to receive a CSF1-R inhibitor and studied for 7 or 28 days after joint injury. Additionally, we profiled synovial fluid samples for CSF1-R from patients with injury to their ACL. Transcriptomic analysis of quadriceps muscle and articular cartilage in CSF1-R inhibitor-treated animals at 7 days after injury revealed elevated chondrocyte differentiation within articular cartilage and enhanced metabolic and contractile gene expression within skeletal muscle. At 28 days post-injury, CSF1-R inhibition attenuated PTOA severity and mitigated skeletal muscle atrophy. Patient synovial fluid CSF1-R levels correlated with matrix metalloproteinase 13, a prognostic marker and molecular effector of PTOA. Our findings support an opportunity for CSF1-R targeting to mitigate the severity of PTOA and muscle atrophy after joint injury.

ORGANISM(S): Mus musculus

PROVIDER: GSE275958 | GEO | 2025/06/25

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2025-06-25 | GSE275957 | GEO
2025-07-05 | GSE236843 | GEO
2022-07-18 | GSE200843 | GEO
2018-11-28 | GSE112641 | GEO
2025-07-05 | GSE236844 | GEO
2021-06-19 | GSE172500 | GEO
2024-12-31 | GSE220167 | GEO
2023-12-06 | GSE230736 | GEO
2023-12-06 | GSE230708 | GEO
2022-06-23 | MSV000089716 | MassIVE