Transcriptomics

Dataset Information

0

Loss of pulmonary tissue protection promotes severe Aspergillus fumigatus infection during Influenza A Virus


ABSTRACT: Invasive pulmonary aspergillosis (IPA) is a severe fungal disease caused by Aspergillus spp. (particularly A. fumigatus or Af) that may spread hematogenously to extrapulmonary organs. IPA is typically associated with a broad spectrum of immunocompromised conditions and immunologic disorders and constitutes a high mortality rate. While the association of influenza as a risk for secondary bacterial infections is well appreciated, emerging evidence indicates that influenza-hospitalized patients demonstrate increased susceptibility to severe aspergillosis infection. In this study, we developed a murine Influenza A Virus (IAV)-Af co-infection model and investigated the role of IAV host response in promoting severe Af infection. Our data show that in a co-infection setting, while IAV suppresses Af-induced CXCL1 and early neutrophil recruitment, no defects in neutrophil phagocytic responses were observed. On the contrary, despite similar fungal burdens and conidial germination between single Af and co-infected lungs, there was greater fungal invasiveness in the early phase of IAV-Af co-infection. These findings suggest that enhanced lung inflammation, vascular injury, and loss of tissue protection in IAV-infecetd lung likely contribute to severe secondary Af infection.

ORGANISM(S): Mus musculus

PROVIDER: GSE276049 | GEO | 2025/07/16

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2017-12-05 | GSE100865 | GEO
2022-05-31 | GSE165694 | GEO
2022-03-02 | GSE174825 | GEO
2023-07-25 | PXD035900 | Pride
2023-07-25 | PXD036077 | Pride
2023-07-25 | PXD041663 | Pride
2024-09-02 | BIOMD0000000546 | BioModels
2024-09-02 | BIOMD0000000711 | BioModels
2024-05-17 | GSE243974 | GEO
2025-05-08 | GSE292329 | GEO