The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse

ABSTRACT: Using EphB2 or the ISC marker Lgr5, we have FACS-purified and profiled intestinal stem cells (ISCs), crypt proliferative progenitors and late transient amplifying cells to define a gene expression program specific for normal ISCs. A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. The intestinal stem cell signature predicts disease relapse in CRC and identifies a stem cell-like population that displays robust tumor- initiating capacity in immunodeficient mice as well as long-term self-renewal potential.

ORGANISM(S): Mus musculus

PROVIDER: GSE27605 | GEO | 2011/03/14

SECONDARY ACCESSION(S): PRJNA138281

REPOSITORIES: GEO