ScRNAseq of brain micrometastasis

ABSTRACT: Heterogeneity of brain micrometastasis was analyzed by terms of intracardiac injection of H2030-BrM cell (lung adenocarcinoma model with tropism to the brain) into mice. After 14 days, mice were sacrified in order to obtain metastatic cells from micrometastases performing vascular co-option and in proliferative pause to study their heterogeneity. Apart from control cells, H2030-BrM with reduced levels of MXD4 (shRNAs), a discovered driver of the prolfierative pause, were also injected and analyzed by scRNAseq to compare their differences.

ORGANISM(S): Homo sapiens

PROVIDER: GSE278126 | GEO | 2026/08/21

REPOSITORIES: GEO