Transcriptomics

Dataset Information

23

HDAC6 and HSP90 control the functions of Foxp3+ T regulatory cells


ABSTRACT: Foxp3+ T-regulatory cells (Tregs) are key to immune homeostasis such that their diminished numbers or function can cause autoimmunity and allograft rejection. Foxp3+ Tregs express histone/protein deacetylases (HDACs) that regulate chromatin remodeling, gene expression and protein function. Pan-HDAC inhibitors developed for oncology enhance Treg production and suppression but have limited non-oncologic applications given their broad effects. We show, using HDAC6-deficient mice and WT mice treated with HDAC6-specific inhibitors, that HDAC6 inhibition promotes Treg suppressive activity in models of inflammation and autoimmunity, including multiple forms of experimental colitis and fully MHC-incompatible cardiac allograft rejection. Many of the beneficial effects of HDAC6 targeting are also achieved by inhibition of the HDAC6-regulated protein, HSP90. Hence, selective targeting of a single HDAC isoform, HDAC6, or its downstream target, HSP90, can promote Treg-dependent suppression of autoimmunity and transplant rejection. Overall design: RNA from three independent samples from magnetically separated CD4+CD25+ Treg of HDAC6 knock out, compared to wild type (C57BL6) control

INSTRUMENT(S): [Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array

ORGANISM(S): Mus musculus  

SUBMITTER: Wayne W Hancock  

PROVIDER: GSE27896 | GEO | 2011-05-01

SECONDARY ACCESSION(S): PRJNA138203

REPOSITORIES: GEO

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2012-03-27 | E-GEOD-27896 | ArrayExpress
2015-04-30 | E-GEOD-36095 | ArrayExpress
2014-07-10 | E-GEOD-36095 | ExpressionAtlas
2015-05-24 | E-GEOD-68991 | ArrayExpress
| GSE95316 | GEO
| GSE74957 | GEO
2014-06-03 | E-GEOD-47989 | ArrayExpress
2014-06-02 | E-GEOD-27434 | ArrayExpress
| GSE27434 | GEO
| GSE35164 | GEO