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Multiomics Analyses Unveil Immune Landscape in Pediatric and Adult Sepsis [scRNA_seq]

ABSTRACT: Sepsis is a leading cause of global mortality, characterized by organ dysfunction due to a dysregulated immune response to infection. This study aims to delineate the immune landscape in sepsis through a combined analysis of single-cell RNA sequencing (scRNA-seq) with TCR and BCR sequencing. A total of 133 samples were analyzed, including PBMCs from healthy adults, adult ICU controls, adult sepsis patients, healthy children, pediatric ICU controls, and pediatric sepsis patients. The integration of scRNA-seq with TCR and BCR sequencing revealed both common and unique immune cell populations across different infection sources and between adults and children. These findings provide insights into the pathophysiology of sepsis and suggest potential targets for personalized therapeutic approaches.

ORGANISM(S): Homo sapiens

PROVIDER: GSE279452 | GEO | 2025/09/28

REPOSITORIES: GEO

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