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Enhanced T cell-monocyte interation allievates malaria-associated acute respiratory distress syndrome : Bulk RNA-seq

ABSTRACT: Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a severe manifestation of malaria with high mortality and no effective treatment. IFN-γ, a key regulator of immunity, plays a role in both promoting and suppressing malaria infection, though its effects on specific cell types remain unclear. In this study, we show that IFN-γ directly enhances CD8+ T cell proliferation, cytotoxicity, and cytokine production in a MA-ARDS mouse model. In IFNGR1-deficient T cells, IFN-γ deficiency led to increased CD8+ expression on Ly6c+ monocytes, enhancing their phagocytic ability. These findings highlight the role of T cell IFN-γ signaling in modulating monocyte function and suggest targeting this pathway could improve T cell-based therapies for MA-ARDS

ORGANISM(S): Mus musculus

PROVIDER: GSE279789 | GEO | 2025/10/01

REPOSITORIES: GEO

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