Transcriptomics

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Assessing the role of FcγRIIIa expression on CD8 T cells


ABSTRACT: Fcγ receptors (FcγRs) are ubiquitously expressed by nearly all lineages of innate and adaptive leukocyte populations, with the notable exception of T cells, which are negative for all classes of FcγRs. While at steady state T cells are negative for all FcγR classes, we observed that a subset of CD8 T cells specifically induces the expression of the activating FcγR, FcγRIIIa, in response to viral infection. We used scRNAseq to compare the transcriptional profile of FcγRIIIa+ and FcγRIIIa- CD8 T cell populations from the lungs of influenza-infected FcγR humanized mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE279890 | GEO | 2025/06/17

REPOSITORIES: GEO

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