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RNA-sequencing analysis of differential expressed genes in TGFβ-treated HK-2 cells after HDAC11 inhibition

ABSTRACT: Renal fibrosis is a pathological damage associated with nearly all forms of kidney disease. Although a recent study has reported an association between upregulation of histone deacetylase 11 (HDAC11) levels in the kidneys and renal fibrosis in several different mouse models, however, the mechanisms remain elusive. Renal fibrosis is characterized by excessive accumulation of extracellular matrix (ECM), which includes type I and IV collagens, fibronectin and α-smooth muscle actin (α-SMA). The tubular epithelial injury and activation of pro-inflammation contribute to excessive collagen deposition in the pathogenesis of renal fibrosis. Here we aim to explore the role and the underlying mechanisms of HDAC11 in the of progression renal fibrosis. we performed RNA transcriptome sequencing to identify the differentially expressed genes (DEGs) between before and after HDAC11 inhibitor (FT895)-intreated HK-2 cells. GSEA analysis showed that the DEGs were highly enriched in the pathways of epithelial mesenchymal transition and inflammatory response, indicating that HDAC11 inhibitor may resistant to TGFβ-induced ECM deposition.

ORGANISM(S): Homo sapiens

PROVIDER: GSE280100 | GEO | 2025/11/01

REPOSITORIES: GEO

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