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Human scRNA-seq of three primary and five metastatic breast cancers

ABSTRACT: A key problem in cancer biology is understanding the phenotypic characteristics of the aggressive cell states present in macrometastases and their molecular underpinnings. Here we report on the cellular constituents of human breast cancer metastases, revealing that these malignant cells are invariably locked in a chimeric cell state. Human BC metastatic cells indeed display a gene-expression profile associated to embryonic development of tubular organs, while also retaining the transcriptional features of the primary tumor subtype.

ORGANISM(S): Homo sapiens

PROVIDER: GSE281580 | GEO | 2026/03/27

REPOSITORIES: GEO

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Human scRNA-seq of three breast cancer metastases and three normal mammary glands

Project description:A key problem in cancer biology is understanding the phenotypic characteristics of the aggressive cell states present in macrometastases and their molecular underpinnings. Here we report on the cellular constituents of human breast cancer metastases, revealing that these malignant cells are invariably locked in a chimeric cell state. Human BC metastatic cells indeed display a gene-expression profile associated to embryonic development of tubular organs, while also retaining the transcriptional features of their original adult mammary luminal lineage.

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