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Gene expression data from SQ-diEG-treated and BBN-induced bladder cancer mouse model at　8 and 16 W

ABSTRACT: Squalene(SQ), a natural triterpene with antioxidant, anti-inflammatory, and immunostimulatory properties, holds promise for cancer therapy. We examined a previously developed, diethylene glycol derivative of squalene (SQ-diEG) and investigated its in vivo anti-carcinogenic effects in bladder cancer. C57BL/6 mice(6–8 weeks old) were treated with 0.025% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) to induce bladder cancer, with SQ-diEG or PBS (control) administered orally from Week 0 to 8 or 16. On the last day of administration, mice was sacrificed and its bladder collect for the RNA extraction.We performed an untargeted whole-transcriptomic analysis to explore the functionality of SQ-diEG. Squalene(SQ), a natural triterpene with antioxidant, anti-inflammatory, and immunostimulatory properties, holds promise for cancer therapy. We examined a previously developed, diethylene glycol derivative of squalene (SQ-diEG) and investigated its in vivo anti-carcinogenic effects in bladder cancer. C57BL/6 mice(6–8 weeks old) were treated with 0.025% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) to induce bladder cancer, with SQ-diEG or PBS (control) administered orally from Week 0 to 8 or 16. On the last day of administration, mice was sacrificed and its bladder collect for the RNA extraction.We performed an untargeted whole-transcriptomic analysis to explore the functionality of SQ-diEG.

ORGANISM(S): Mus musculus

PROVIDER: GSE281689 | GEO | 2025/07/18

REPOSITORIES: GEO

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